Hepatorenal Syndrome Type 1: Current Challenges And Future Prospects

Hepatorenal Syndrome Type 1: Current Challenges And Future Prospects

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Antonio Facciorusso Gastroenterology shibori dot fabric Unit, University of Foggia, Foggia, ItalyCorrespondence: Antonio FacciorussoGastroenterology Unit, Department of Medical Sciences, University of Foggia, AOU Ospedali Riuniti, Viale Pinto, 1, Foggia 71100, ItalyTel +39 0881732110Fax +39 0881733545Email antonio.facciorusso@virgilio.itAbstract: Renal dysfunction represents a dreadful complication of advanced liver cirrhosis.

In addition to the traditional types of acute kidney injury (AKI) that can occur in the general population, cirrhotics might experience a different kind of renal dysfunction, called hepatorenal syndrome (HRS).The exact definition of HRS is a functional renal dysfunction caused by overactivity medline remedy phytoplex protectant z-guard paste of the endogenous vasoactive systems (in particular intrarenal circulation) which lead to reduced renal perfusion.Type I HRS (HRS-1) is characterized by an abrupt deterioration in renal function (in less than 2 weeks), defined by a doubling of baseline sCr to >2.

5 mg/dL or a 50% reduction in the initial 24 hrs creatinine clearance to   Keywords: kidney, liver cirrhosis, terlipressin, mortality.